Panadol Extra

Panadol Extra pack shot

Fights 5 types of tough pain1

With a dual formulation that fights tough pain such as migraine headache, tension headache,  period pain, dental pain and muscle aches and pains.2-7

The addition of caffeine to paracetamol enhances the analgesic effects of paracetamol.8-10

Graph showing pain-relief differences between Panadol Extra, naproxen sodium and placebo

Effective pain relief for tension-type headache (TTH)5

Panadol Extra and naproxen provided significantly better pain relief vs. placebo.5 Pain-relief effects were similar to each other (p<0.05). The study concludes that PCF is well tolerated.11*

Graph showing time taken to achieve total pain relieve (TOPTAR) between Panadol Extra and sumatriptan

Effective relief for migraines6

In a randomised, double-blind, cross-over phase IV, controlled trial, 92 patients with migraine were given either paracetamol 1000 mg + caffeine 130 mg or sumatriptan 50 mg.6

Panadol Extra was as effective as sumatriptan (generally used to treat migraines) for pain relief.6

Graph showing pain relief achieved with Panadol Extra, paracetamol alone, caffeine alone and placebo.

Significant relief from period pain2

This was a single-dose, placebo-controlled, double blind three-way crossover study in women with moderate-to-severe dysmenorrhoea (n=320). The total pain relief (TOTPAR) was assessed for 1000 mg paracetamol + 130 g caffeine, 1000 mg paracetamol alone and 130 mg caffeine alone or placebo.

Two tablets of Panadol Extra provided significantly more pain relief than standard paracetamol tablets.2

What can Panadol Extra do for Julie?

Image of a patient pain free from menstrual pain

Julie needs help for her period pain

Julie is a young mum of two and works full time. Like her mother and grandmother, she’s suffered from primary dysmenorrhoea (period pain) since her teens. Recently,  Julie has developed gastritis -  possibly as a result of irregular meals and stressful days working and looking after the household.

She needs something to help manage her period pain, without aggravating her gastric problem.

Panadol Extra with paracetamol and caffeine offers fast, effective relief for tough pain such as period pain.

Recommend Panadol Extra to fight tough pain

Panadol Extra pack shot

Panadol Extra

Fights 5 types of tough pain - migraine headache, tension headache,  period pain,  dental pain and muscle aches and pains.1

Panadol Extra product details

  • Each tablet contains paracetamol 500 mg and caffeine 65 mg.

    Also includes excipients: maize starch, starch-pregelatinised maize, povidone, potassium sorbate, purified talk, stearic acid, croscarmellose sodium, hypromellose and glycerol tracetin.

  • Special warnings and precautions for use

    Do not use with any other paracetamol containing products. The concomitant use with other products containing paracetamol may lead to an overdose.

    Paracetamol overdose may cause liver failure which may require a liver transplant or lead to death.

    Underlying liver disease increases the risk of paracetamol-related liver damage. Patients who have been diagnosed with liver or kidney impairment must seek medical advice before taking this medication.

    Cases of hepatic dysfunction/failure have been reported in patients with depleted gluthathione levels such as those who are severely malnourished, anorexic, have a low body mass index or are chronic heavy users of alcohol or have sepsis.

    In patients with gluthathione depleted states, the use of paracetamol may increase the risk of metabolic acidosis.

    If symptoms persist, medical advice must be sought. If cold and flu symptoms persist for longer than 7 days, medical advice must be sought.

    Excessive intake of caffeine (e.g. coffee, tea and some canned drinks) should be avoided while taking this product.

    Keep out of the reach and sight of children.

    Paracetamol-caffeine is not recommended:

    • for children under the age of 12 years
    • concomitant use of drugs containing lithium (caffeine can increase the elimination of lithium from the body.)
    • concomitant use of warfarin and other coumarins which may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses (of paracetamol) have no significant effect.
    • during pregnancy (caffeine is not recommended for use during pregnancy due to the possible increased risk of spontaneous abortion associated with caffeine consumption)
    • during breast feeding (caffeine in breast milk may potentially have a stimulating effect on breast fed infants but significant toxicity has not been observed)


    This product is contraindicated in patients with a previous history of hypersensitivity to paracetamol, caffeine or excipients.

  • Body system

    Undesirable effect


    Blood and lymphatic system disorders



    Immune system disorders


    Cutaneous hypersensitivity reactions including, among others, skin rashes, angioedema and Steven Johnson syndrome and toxic epidermal necrolysis

    Respiratory, thoracic and mediastinal disorders

    Bronchospasm in patients sensitive to aspirin and other NSAIDs

    Hepatobiliary disorders

    Hepatic dysfunction


    Central nervous system

    Dizziness, headache

    Cardiac disorders


    Psychiatric disorders

    Insomnia, restlessness, anxiety and irritability, nervousness

    Gastrointestinal disorders

    Gastrointestinal disturbances

    When the recommended paracetamol-caffeine dosing regimen is combined with dietary caffeine intake, the resulting higher dose of caffeine may increase the potential for caffeine-related adverse effects.

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Educational resources

Educational resources

Access detailed clinical information about Panadol Extra.

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