The science of caffeine and paracetamol

Paracetamol chemical structure

Paracetamol basics

Globally, paracetamol is one of the most used analgesic and antipyretic over-the-counter medicines.1

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The mechanism of action of paracetamol is complex and involves inhibition of prostaglandins to exert its analgesic effect. 1

Caffeine chemical structure

Caffeine basics

First discovered in 350 A.D., caffeine was extracted as an active compound in 1819. It is the most commonly used legal psychoactive drug and is a chemical relative of theophylline (used in treatment of asthma).2,3 Known for some of its effects such as increasing metabolic activity and heart rate, alertness, wakefulness and concentration, for several decades it has been combined with other medications as an analgesic adjuvant. 2,3

Discover the Panadol product with paracetamol and caffeine

Panadol Extra pack shot

Panadol Extra

Fights 5 types of tough pain - migraine headache,  tension headache,  period pain,  dental pain and muscle aches and pains.5

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Woman with migraine

Headaches and migraines

Learn more about headaches and migraines.

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Migraine CPD

Primary Care Management of Migraine

Educating pharmacists on the best-practice management of migraine.

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Educational resources

Educational resources

Access detailed clinical information about Panadol.

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