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Multicenter, randomized, double-blind, parallel-group, 8-week study evaluated 454 patients to compare the effectiveness and tolerability of FPANS 200 mcg once-daily monotherapy with oral cetirizine 10 mg once-daily combination therapy for 8 weeks in the prophylactic treatment of seasonal allergic rhinitis. Patients were randomly assigned to 2 treatment groups. One treatment group was assigned to take FPANS 200 mcg once daily in the morning plus 1 placebo tablet (n=227) and the other group was assigned to take FPANS 200 mcg once daily in the morning plus 1 cetirizine 10-mg tablet (n=227). A majority of patients reported experiencing moderate or severe seasonal allergic rhinitis for more than 10 years. Treatment began before the expected hay fever season.1
Benincasa C, Lloyd RS. Evaluation of Fluticasone Propionate Aqueous Nasal Spray Taken Alone and in Combination with Cetirizine in the Prophylactic Treatment of Seasonal Allergic Rhinitis. Drug Invest 1994;8(4):225-233.