Panadol Advance

Panadol Advance pack shot

Advanced absorption1 for fast pain relief 2*

Panadol Advance (fast-dissolving acetaminophen) reached the therapeutic threshold 15 min faster than did standard acetaminophen (0.43 h vs. 0.68 h, P < 0.05).1

Optizorb technology

Images showing the rapidity of Panadol Advance disintegration in the stomach compared to standard paracetamol tablets

Panadol Advance gets to work in 5 minutes1

Gamma scintigraphic images (scintigraphy is a form of radio-imaging or scanning that involves injecting a radioisotope that emits gamma rays, into a patient’s vein, which is captured as images)10 of the stomach showed that maximum plasma concentration is reached at least 25% faster for Panadol Advance compared to standard acetaminophen tablets in fasted and fed states.1

Graph that shows Panadol Advance is absorbed faster compared with standard paracetamol tablets

Panadol Advance (fast-dissolving acetaminophen) reached the therapeutic threshold 15 min faster than did standard acetaminophen (0.43 h vs. 0.68 h, P < 0.05).1

The mean time to complete disintegration was 5 times faster for Panadol advance (FD-APAP*) compared with standard acetaminophen (12.9 vs. 69.6 min, P < 0.0001).1

*FD-APAP = fast-dissolving acetaminophen

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Recommend Panadol Advance for faster relief compared to standard paracetamol.

Panadol Advance product details

  • Ingredients3

    Each film coated tablet contains:Paracetamol 500 mg

    Also, as inactive ingredient: pregelatinised starch, Calcium Carbonate, Alginic acid, Crospovidone, Magnesium Stearate, Colloidal anhydrous silica, Nipasept Sodium* & purified water.

    Film coating: Opadry white**, Carnauba wax & purified water

    *Nipasept Sodium consists of Sodium methyl parahydroxybenzoate, Sodium ethyl parahydroxybenzoate & Sodium propyl parahydroxybenzoate.

    ** Opadry white consists of Hypromellose, Titanium dioxide, Macrogol and Polysorbate 80

  • Precautions and contradications3

    Warnings and Precautions for use:(3)

    Caution is advised in the administration of paracetamol to patients with moderate or severe renal or severe hepatic impairment. The hazard of overdose is greater in those with moderate and severe liver disease.

    Do not exceed the stated dose.

    Patients should be advised not to take other paracetamol-containing products concurrently. If symptoms persist, consult your doctor.

    Prolonged use except under medical supervision may be harmful.

    This product should only be used when clearly necessary.

    Contains parahydroxybenzoates which may causeallergic reactions possibly delayed).

    Contraindications:

    Hypersensitivity to paracetamol or any of the other constituents.

    Use in children under 6 years of age.

    Interaction with other medicinal products and other forms of interaction:

    The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by cholestyramine.

    The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.

    Pregnancy & Lactation:

    There is epidemiological evidence of the safety of paracetarnol in human pregnancy. Paracetamol is mild analgesic of choice during pregnancy.

    However as with all drugs, caution should be exercised in its use during the first trimester.

    Lactation

    Paracetamol is excreted in breast milk. However the level of paracetamol present is not considered to be harmful.

  • Side effects3

    Body system

    Undesirable effect

    Frequency

    Blood and lymphatic system disorders

    Thrombocytopenia

    Very rare

    Immune system disorders

    Anaphylaxis

    Cutaneous hypersensitivity reactions including among others, skin rashes, angioedema and Steven Johnson syndrome and toxic epidermal necrolysis

    Very rare

    Respiratory, thoracic and mediastinal disorders

    Bronchospasm in patients sensitive to aspirin and other NSAIDs

    Very rare

    Hepatobiliary disorders

    Hepatic dysfunction

    Very rare

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Paracetamol chemical structure

Paracetamol

Paracetamol or acetaminophen is one of the most used analgesic and antipyretic over-the-counter drugs globally.5

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A presentation on acute and chronic pain management with physiotherapy.

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A simple-to-use tool to help you counsel your patients/customers on appropriate medication use, tailor made for pharmacists.

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