Day & Night Nurse

Day & Night Nurse Capsules. (Day capsule: Paracetamol 500 mg, pseudoephedrine hydrochloride 30 mg, pholcodine 5 mg. Night capsule: Paracetamol 500 mg, promethazine HCl 10 mg, dextromethorphan HBr 7.5 mg). Indications: Symptomatic relief of colds, chills and influenza. Dosage: Adults and children 16 years and over: Day Capsules: 2 capsules every 4 hours. Max 3 doses in 24 hours. Min dosage interval: 4 hours. Night Capsules: 2 capsules before bed. Max 1 dose per night. Wait at least 4 hours after last dose of Day capsules before taking. Max duration of use without medical advice: 3 days. Contraindications: Hypersensitivity to any of the ingredients or excipients, hyperexcitability, patients using other sympathomimetics or monoamine oxidase inhibitors (MAOIs) or for two weeks after stopping MAOI treatment. Patients taking oxazolidinone antibiotics, beta blockers or antihypertensives, or those with severe hypertension or severe coronary artery disease, severe renal impairment, bronchiolitis or bronchiectasis. Warnings and precautions: Contains paracetamol. Avoid use of other antihistamine-containing preparations, including topical and cough and cold medicines. Patients with severe hepatic impairment, mild to moderate renal impairment, chronic or persistent cough, glaucoma, hypertension or cardiovascular problems, prostatic hypertrophy, urinary retention, epilepsy, diabetes, hyperthyroidism and phaeochromocytoma, or those taking antidepressants. Product should be discontinued immediately, and medical advice sought with sudden abdominal pain or rectal bleeding. Stop use immediately with sudden loss of vision or decreased visual acuity. Discontinue use if severe skin reactions or fever occur within the first 2 days of treatment. Use with caution in the elderly, who are more likely to experience confusion and paradoxical excitation. Caution in patients with depleted glutathione levels.  Alcohol should be avoided. Prolonged use may lead to addiction, even at therapeutic doses. Concomitant use with serotonergic agents can result in serotonergic effects, including serotonin syndrome.  Seek medical advice if symptoms persist. Should not be used with other paracetamol-containing products, decongestants, antihistamines (including those used on the skin) or cough and cold medicines. Caution must be used with patients with a history of drug abuse including dextromethorphan abuse. Caution should be exercised in patients who are slow metabolizers of CYP2D6 or use CYP2D6 inhibitors. Medical advice should be sought if symptoms persist, or are accompanied by high fever, skin rash or persistent headache. May cause urine pregnancy tests to produce false results. Lowest effective dose and shortest duration of treatment should be considered during pregnancy. Product should only be used on medical advice during lactation. Immediate medical advice should be sought in the event of an overdose. Side effects: See SPC for full details. Hypersensitivity reactions including anaphylaxis, drug dependence and drug withdrawal syndrome, skin rashes, SJS, drowsiness, dizziness, nausea, vomiting abdominal discomfort, dry mouth, thrombocytopenia, bronchospasm, hepatic dysfunction, confusion, disorientation, paradoxical excitation, increased blood pressure, tachycardia, palpitations, blurred vision and urinary retention. Legal category: P. Product licence number: PL 44673/0068. MAH: GlaxoSmithKline Consumer Healthcare (UK) Trading Limited, Brentford, TW8 9GS, U.K. RRP (excl. VAT): £7.08 Text prepared: September 2020.