The science behind Sensodyne: NOVAMIN Technology
Sensodyne Repair & Protect Deep Repair* is specially formulated with NovaMin
Formulations with NovaMin form a protective layer over exposed dentine for lasting protection from dentine hypersensitivity.**1-3
*Forms a protective layer over the sensitive parts of the teeth Brush twice a day for lasting sensitivity protection.**With twice-daily brushing
NovaMin formulations build a hydroxyapatitelike layer over and within dentine tubules
NovaMin is specially formulated in Sensodyne Repair & Protect to repair* exposed dentine:1–8
- Once in contact with saliva, NovaMin initiates a cascade of ionic exchanges
- This results in a rise in pH level in the localised environment, which allows NovaMin to bind to collagen fibres in exposed dentine
- Once bound to dentine, NovaMin particles act as calcium and phosphate reservoirs, forming a robust and reparative* hydroxyapatite-like layer over exposed dentine tubules to help protect against dentine hypersensitivity pain
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection.
NovaMin forms a robust hydroxyapatite-like layer over exposed dentine and within exposed dentine tubules*1-3
An in vitro cross-section, SEM image of hydroxyapatite-like layer formed by supersaturated NovaMin solution in artificial saliva after five days (no brushing).1
SEM, scanning electron microscopeSEM image adapted from Earl et al. 20111*It forms a protective layer over the sensitive area of the teeth. Brush twice a day for lasting sensitivity protection
NovaMin helps form a protective layer over exposed dentine1,2
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The hydroxyapatite-like layer bonds to the collagen in exposed dentine1
TEM image of dentine at 2000nm
The occluded dentine tubule runs from top to bottom of the image.1
TEM image of dentine at 500nm
High magnification showing NovaMin as the occluding material adjacent to inner wall of dentine tubule.1
TEM image of dentine at 200nm
Very high magnification of the previous image showing crystalline calcium phosphate deposited adjacent to and among collagen fibres of dentine.1
TEM, transmission electron microscope TEM images are of dentine after 5 days of in vitro NovaMin treatment and are adapted from Earl et al. 20111
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NovaMin is activated in the mouth to provide protection from dentine hypersensitivity1,2,4,7-12
Scanning electron microscope images of the dentine surface before brushing with NovaMin-formulated toothpaste and the resistant layer formed after2
NovaMin is a Bioglass that uses the natural building blocks of teeth4 to remineralise exposed dentine, forming a crystalline hydroxyapatite layer.1,2,4,7-12
- Calcium and phosphorous are the two main components of hydroxyapatite, the mineral which teeth are made of – this is key to the mode of action of NovaMin
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NovaMin helps create a reparative* layer that is structurally similar to dentine*1,2,13
The Ca:P ratio of the hydroxyapatite-like layer is ~1.67, similar to that of dentine and hydroxyapatite1
When overlaid, energy-dispersive X-ray (EDX) microscopy plots of the new reparative* layer (hydroxyapatite-like layer) and the dentine surface confirm their similar inorganic compositions.
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection
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A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated a reduction in the proportion of teeth with dentine hypersensitivity14,15
53% reduction in the proportion of teeth qualifying as sensitive in response to an evaporative air test (Schiff Sensitivity Scale) after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.*14,15
Chart adapted from GSK Data on File RH0189714*Qualifying sensitive teeth met the following inclusion criteria: signs of EAR, GI ≤1, clinical mobility=0, no dentition exclusion and sensitivity to a qualifying air blast. ITT population (n=75)
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A clinical study with continued twice-daily use of 5% NovaMin toothpaste demonstrated improvement in dentine hypersensitivity in response to tactile pressure*14,15
2.2x improvement in dentine hypersensitivity in response to tactile pressure after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NovaMin.*14,15
Chart adapted from GSK Data on File RH0189714*Maximum tactile pressure was 80g. An increase in tactile threshold indicates an improvement in dentine hypersensitivity. ITT population (n=75)
Recommend Sensodyne NovaMin products for your patients with dentine hypersensitivity.
Sensodyne Repair & Protect Deep Repair* toothpaste
Sensodyne Repair & Protect Deep Repair* toothpaste is powered by NovaMin.
*Forms a protective layer over the sensitive parts of the teeth. Brush twice a day for lasting sensitivity protection.
Sensodyne – the No.1 brand for sensitive teeth16
