Voltral 12-Hour 2.32% Emulgel

Voltral 12-hour 2.32% Emulgel product image

Voltral 12-hour 2.32% Emulgel − eases joint pain and inflammation all day long when applied twice daily1

Provides up to 12 hours of relief from joint pain through an anti-inflammatory action.1

Contains diclofenac, a potent non-steroidal anti-inflammatory drug (NSAID) with effective analgesic, anti-inflammatory and antipyretic properties.2

Diagram showing the concentrations of diclofenac reaching the various tissues beneath the skin of the knee following topical application3

Diclofenac gets deep into the joint area3

After topical administration, diclofenac is distributed to the subcutaneous tissues, muscle, synovial tissues and synovial fluid, the latter tissues typically being most likely to be driving joint pain.3 Its chemical properties support retention within the joint where it is needed, rather than the blood stream.3,4

Voltral 12-hour is specially formulated to help the anti-inflammatory ingredient get through the skin.5,6 It contains a permeation enhancer for increased delivery of diclofenac through the skin.6*

The deep penetration of Voltral 12-hour makes it suitable for the treatment of joint pain related to trauma of the tendons, ligaments, muscles and other joint tissues as well as localised soft-tissue rheumatism.5

*Voltral 12-hour (2.32%) Emulgel compared with Voltral (1.16%) Emulgel (in vitro study) when measured over 24 hours.

Man holding ankle

Provides up to 12 hours of relief from joint pain1

Voltral 12-hour has proven clinical efficacy: in a study of acute ankle sprain, patients experienced a 65% reduction in pain from baseline after 4 days, with additional benefits in terms of reductions in swelling vs placebo.1

Voltral 12-hour provides all-day joint-pain relief, meaning convenient twice-daily application is all that is needed.1,5

The lowest number-needed-to-treat (NNT) for Voltral Emulgel* vs other topical NSAIDs in acute musculoskeletal pain7,8

A Cochrane Review of 61 studies of topical NSAIDs compared with placebo (>8000 patients) reported that Voltral Emulgel has the lowest NNT (1.8) of topical NSAIDs in acute musculoskeletal pain, including topical ibuprofen (3.9).7.8*

This means that for every single patient you treat with Voltral Emulgel over other topical NSAIDs, you have a better chance of giving them the significant pain relief that helps get them back on their feet and enjoying life again.7

*1.16% and 2.32% Voltral Emulgel formulations included in the review.†vs topical ibuprofen, ketoprofen, benzydamine, piroxicam and indomethacin.

Very low systemic exposure

Graphic depicting systemic exposure with topical or oral diclofenac3

Low systemic absorption, for a lower risk of systemic side effects3,5,9

Voltral 12-hour has a low systemic exposure3,5,10 meaning a reduced risk of systemic side effects and drug–drug interactions.3,5

That includes a reduced systemic side-effect risk vs oral NSAIDs (e.g. gastrointestinal events).11.12*

*There is an increased risk of mild dermatological side effects (e.g. skin irritation) with topical diclofenac, but this is non-serious and reversible.

Supported by treatment guidelines

Osteoarthritis treatment algorithm14–16

Providing additional pain-relief alongside paracetamol13–15*

Clinical guidelines support the use of paracetamol for chronic osteoarthritis pain of the knee,13,16 hand13 and hip,16 with the option of adding topical NSAIDs for further pain relief,13,16 including for the treatment of short-term pain flares that often accompany chronic osteoarthritis pain.16 However, more-recent guidelines do not recommend the use of paracetamol (alone or in combination with topical NSAIDs) for the treatment of osteoarthritis.17

*Current Osteoarthritis Research Society International (OARSI) guidelines do not recommend treating osteoarthritis with paracetamol.Current OARSI guidelines do not recommend treating osteoarthritis with oral or transdermal opioids.

What can Voltral 12-hour do for Naureen?


Naureen needs to regain mobility by easing joint stiffness

Naureen wakes up with joint pain and stiffness each morning and has difficulty climbing stairs but does not want this to control her life or her choices.

She already receives multiple oral medications and is concerned that adding more will increase her risk of side effects.

Naureen tries to stay active by gardening and going for walks, but this can sometimes be a struggle.

She wants sustained relief from her pain so that she can do the things she enjoys.

Voltral 12-hour provides clinically proven joint pain relief7 in a convenient, twice-daily application, without the worry of adding more oral medications.

Recommend Voltral 12-hour to your patients for relief of joint pain and inflammation all day long when applied twice daily

Voltral 12-hour 2.32% Emulgel product image

Voltral 12-hour

For patients who are looking for long-lasting relief from joint pain and inflammation, using a topical formulation.

Voltral 12-hour product details

  • Ingredients5

    1 g of Voltral 12-hour 2.32% Emulgel contains 23.2 mg of diclofenac diethylamine, which corresponds to 20 mg of diclofenac sodium.5

    Also contains excipients (butylhydroxytoluene, carbomer, cocoyl caprylocaprate, diethylamine, isopropyl alcohol, liquid paraffin, macrogol cetostearyl ether, oleyl alcohol, propylene glycol, perfume eucalyptus sting, purified water).5

  • Directions5

    For cutaneous use only. Patients should consult their doctor if the condition does not improve or worsens within 7 days of starting treatment.

    The duration of treatment depends on the indication and clinical response. The product should not be used for more than 14 days for soft-tissue injuries or soft-tissue rheumatism, or 21 days for arthritis pain, unless recommended by a doctor.

    For adults and adolescents aged 12 and over

    Voltral 12-hour 2.32% Emulgel provides lasting pain relief of up to 12 hours (applied two times daily - morning and evening). It should be rubbed gently into the skin at the affected area. The amount needed depends on the size of the painful area: 2 g to 4 g (cherry to walnut sized) is sufficient to treat an area of about 400–800 cm. After application, the hands should be washed, unless they are the site being treated.

  • Warnings and precautions5

    The possibility of experiencing systemic adverse events (those associated with the use of systemic forms of diclofenac) should be considered if topical diclofenac is used at a higher dosage or for a longer period of time than recommended. Topical diclofenac should be applied only to intact, non-diseased skin, and not to skin wounds or open injuries. It should not be allowed to come into contact with the eyes or mucous membranes, and should not be ingested. After rubbing the gel into the skin, non-occlusive bandages can be used, however without an airtight occlusive dressing.

    Contains propylene glycol esters, which may cause mild, localised skin irritation in some people. Also contains butylhydroxytoluene, which may cause local skin reactions (e.g. contact dermatitis) or irritation to the eyes or mucous membranes. Discontinue if a skin rash develops after applying.


    • Known hypersensitivity to diclofenac or to any of the excipients
    • Patients in whom asthma, angioedema, urticaria, or acute rhinitis are precipitated by acetylsalicylic acid or other NSAIDs
    • During the last trimester of pregnancy

    For the full description of special warnings and precautions with Voltral 12-hour 2.32% Emulgel, please consult your local Summary of Product Characteristics.

  • Side effects5

    The following convention has been utilised for the classification of undesirable effects: very common (≥ 1/10) common (≥ 1/100 to < 1/10); uncommon (≥ 1/1,000 to < 1/100); rare (≥ 1/10,000 to < 1/1,000); very rare (< 1/10,000):

    Body system

    Adverse reaction


    Infection and infestation

    Rash pustular

    Very rare

    Immune system disorders

    Angioedema, hypersensitivity (including urticaria)

    Very rare

    Respiratory, thoracic and mediastinal disorders


    Very rare

    Skin and subcutaneous tissue disorders Dermatitis (including contact dermatitis), rash, erythema, eczema, pruritus Common
    Dermatitis bullous Rare
    Photosensitivity reaction Very rare

    For the full list of adverse reactions with Voltral 12-hour 2.32% Emulgel, please consult your local Summary of Product Characteristics.

Woman clutching knee

Joint pain and osteoarthritis

Learn more about osteoarthritis and how it can be managed with physiotherapy.


Educational resources

Educational resources

Access detailed clinical information on Voltral 12-hour Emulgel.


Patient care resources

Patient care resources

Download information on joint pain for your patient.