Pronamel science

The optimized formulation of Pronamel^1–10

Pronamel is designed to protect against the effects of enamel erosion due to dietary acids. Its fluoride-optimized formula tips the balance back toward the remineralization of enamel, rehardens teeth, and leaves enamel more resilient to subsequent enamel challenges.^2-4

Specially designed to deliver more fluoride to the acid-weakened enamel*^3,5

Pronamel contains 1150ppm fluoride in an optimized formulation designed to maximize fluoride delivery.³ By omitting components that inhibit fluoride uptake, which are present in many fluoride toothpastes, Pronamel dual-protection formulation enhances remineralization and inhibits demineralization, strengthening and protecting enamel.^2-6

Pronamel optimized formulation:

Delivers up to 10x higher fluoride uptake vs a non-optimized fluoride toothpaste**
No phosphates^5,7
No polyvalent metal ions⁸
High fluoride availability⁸
No SLS⁹
Neutral pH¹⁰
Enhances remineralization and inhibits demineralization^2-6

SLS, sodium lauryl sulphate*Compared with tested, non-optimized fluoride toothpastes**Based on an in vitro study in which fluoride uptake was measured at 10um depth [vs. Colgate Enamel Health] Sourced and tested in 2014

How enamel is affected by enamel erosion

Enamel undergoes natural dynamic cycles of remineralization and demineralization,^11-13 normally favoring remineralization due to mineral-rich saliva, which helps neutralize acidity and reharden enamel.

However, exposure to gastric or dietary acids can demineralize and weaken enamel, causing it to lose some of its mineral content. Because the tooth’s recovery process is slow, if the acid attack happens frequently, the enamel will not have a chance to repair itself.

Not all fluoride toothpastes are the same

Pronamel maintains higher levels of fluoride in saliva 1 hour post brushing

In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher levels of fluoride in subjects’ saliva 1 hour after brushing.²

Adapted from GSK data on file RH02217, 2014²
Pronamel creates an environment in the mouth that supports fast remineralization ³

In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher calcium bioavailability in subjects’ saliva.²

Adapted from GSK data on file RH02217, 2014².*Tested on Pronamel & Colgate Sensitive Enamel Protect (both containing 1150ppm fluoride as NaF).
Pronamel enhances remineralization by delivering up to 10x more fluoride uptake into enamel in vitro ^*3

Up to 10x higher fluoride uptake* in vitro vs. a non-optimized, 1150ppm fluoride NaF toothpaste³

In laboratory studies, Pronamel delivered more fluoride, deeper into the enamel for fast remineralization vs. a non-optimized fluoride toothpaste.*¹⁶

In vitro cross-sectional DSIMS images of enamel surfaces

DSIMS, dynamic secondary ion mass spectrometry*Based on an in vitro study in which fluoride uptake was measured at 10um depth [vs. Colgate Enamel Health] Sourced and tested in 2014;†Colgate Enamel Health. Sourced and tested in 2014.
Pronamel improves mineral uptake, leaving enamel more resilient to subsequent acid challenge ⁸

In an in situ study, Pronamel increased the surface microhardness of acid-weakened enamel, leaving it stronger and more resilient to dietary acid challenges,⁸ with 54% greater surface microhardness recovery vs. a non-optimized fluoride toothpaste.⁸

Adapted from Barlow et al. 2009⁷ Colgate Sensitive Multi Protection Sourced and Tested in 2008.
Pronamel locks in more minerals for superior inhibition of demineralization ^*4

3.8x greater protection from demineralization* in vitro vs. a non-optimized, 1150ppm fluoride NaF toothpaste⁴

In laboratory studies, Pronamel inhibited demineralization of enamel, locking in more minerals vs. a non-optimized fluoride toothpaste.*⁴

In vitro cross-sectional BSE-SEM images of enamel surface lesions

Adapted from GSK data on file 161181.*Based on overall mineral loss. †Colgate Enamel Health Mineral Repair sourced and tested in 2016
A gentle formulation helps ensure minimal wear of acid-weakened enamel ¹⁴

Pronamel has a low abrasion formula, helping to maintain the structural integrity of the enamel surface.*¹⁴

In vitro SEM cross-sectional images of enamel surface structure

Pronamel products are designed to help protect against enamel erosion.^3,4,8

Pronamel products are designed to help protect against enamel wear due to dietary acids^7,17,19–21

Sensodyne Pronamel – helping protect your patients against the effects of enamel erosion due to dietary acids

Enamel erosion

Find out more about enamel erosion

Find out more

The Sensodyne Pronamel range

Pronamel strengthens and protects tooth enamel. See which formula in our product line is right for your patients.

Find out more

Patient care resources

Download resources for your patients.

Find out more

References

.US Patent app no 11/909210
GSK data on file RH02217. December, 2014.
GSK data on file 144803
GSK data on file 161181. May, 2016.
Newby CS et al. J Clin Dent 2006; 40:306
Layer TM. J Clin Dent 2009; 20:199–202.
Zero DT et al. Caries Res 2000; 34:344.
Barlow AP et al. J Clin Dent 2009; 20:192–198.
Barkvoll P et al. Caries Res 1988; 22:139–144.
Friberger P. Scand J Dent Res 1975; 83:339–344.
Lussi A et al. The role of diet in aetiology of acid erosion. Caries Res, 2004; 38 (Suppl 1): 34-44
Zero D. Erosion – chemical and biological factors of importance to the dental practitioner. Int Dent J 2005; 55: 285-290
GSK data on file 133333. 2016.
GSK data on file 162366. June, 2016.

CHUS/CHSEN/0052/18

Pronamel science

The optimized formulation of Pronamel^1–10