The Optimized Formulation Of Pronamel1–9
Specially Designed to Release More Fluoride to the Acid-Weakened Enamel2,4
Pronamel contains 1150ppm fluoride in an optimized formulation designed to maximize fluoride delivery.2 By omitting components that inhibit fluoride uptake, which are present in many fluoride toothpastes, Pronamel dual-protection formulation enhances remineralization and inhibits demineralization, strengthening and protecting enamel.1-5
Pronamel optimized formulation:
- Delivers up to 10x higher fluoride uptake vs a non-optimized fluoride toothpaste*
- No phosphates4,6
- No polyvalent metal ions
- High fluoride availability7
- No SLS**8
- Neutral pH9
- Enhances remineralization and inhibits demineralization1-5
*Based on an in vitro study in which fluoride uptake was measured at 10um depth(vs. Colgate Enamel Health, sourced and tested in 2014)** Sodium Lauryl Sulfate
How Enamel is Affected by Enamel Erosion
Enamel undergoes natural dynamic cycles of remineralization and demineralization,10-12normally favoring remineralization due to mineral-rich saliva, which helps neutralize acidity and reharden enamel.
However, exposure to gastric or dietary acids can demineralize and weaken enamel, causing it to lose some of its mineral content. Because the tooth’s recovery process is slow, if the acid attack happens frequently, the enamel will not have a chance to repair itself.
Not All Fluoride Toothpastes Are The Same
In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher levels of fluoride in subjects’ saliva 1 hour after brushing.1
Adapted from GSK data on file RH02217, 20141
In an in situ study against a non-optimized fluoride toothpaste, the optimized Pronamel formulation maintained higher calcium bioavailability in subjects’ saliva.1
Adapted from GSK data on file RH02217, 20141.*Tested on Pronamel & Colgate Sensitive Enamel Protect (both containing 1150ppm fluoride as NaF).
Up to 10x higher fluoride uptake* in vitro vs. a non-optimized, 1150ppm fluoride NaF toothpaste2
In laboratory studies, Pronamel delivered more fluoride, deeper into the enamel for fast remineralization vs. a non-optimized fluoride toothpaste.*2
In vitro cross-sectional DSIMS images of enamel surfaces
DSIMS, dynamic secondary ion mass spectrometry*Based on an in vitro study in which fluoride uptake was measured at 10um depth (vs. Colgate Enamel Health, sourced and tested in 2014)†Colgate Enamel Health. Sourced and tested in 2014.
In an in situ study, Pronamel increased the surface microhardness of acid-weakened enamel, leaving it stronger and more resilient to dietary acid challenges,7 with 54% greater surface microhardness recovery vs. a non-optimized fluoride toothpaste.7
Adapted from Barlow et al. 20097 Colgate Sensitive Multi Protection Sourced and Tested in 2008.
3.8x greater protection from demineralization* in vitro vs. a non-optimized, 1150ppm fluoride NaF toothpaste3
In laboratory studies, Pronamel inhibited demineralization of enamel, vs. a non-optimized fluoride toothpaste.*3
In vitro cross-sectional BSE-SEM images of enamel surface lesions
Adapted from GSK data on file 161181.*Based on overall mineral loss vs a non-optimized toothpaste †Colgate Enamel Health Mineral Repair sourced and tested in 2016.
*Colgate Enamel Health. Sourced and tested 2016.**Pronamel Daily Protection and Pronamel Extra Fresh only.
Pronamel has a low abrasion formula, helping to maintain the structural integrity of the enamel surface.*13
In vitro SEM cross-sectional images of enamel surface structure.*Colgate Enamel Health. Sourced and tested 2016.**Pronamel Daily Protection and Pronamel Extra Fresh only.