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Multicenter, randomized, double-blind, parallel-group, 8-week study evaluated 454 patients to compare the effectiveness and tolerability of FPANS 200 mcg once-daily monotherapy with oral cetirizine 10 mg once-daily combination therapy in the prophylactic treatment of seasonal allergic rhinitis. Patients were randomly assigned to 2 treatment groups. One treatment group was assigned to take FPANS 200 mcg once daily in the morning plus 1 placebo tablet (n=227) and the other group was assigned to take FPANS 200 mcg once daily in the morning plus 1 cetirizine 10-mg tablet (n=227). A majority of patients reported experiencing moderate or severe seasonal allergic rhinitis for more than 10 years. Treatment began before the expected hay fever season and continued for 8 weeks.
Benincasa C, Lloyd RS. Evaluation of Fluticasone Propionate Aqueous Nasal Spray Taken Alone and in Combination with Cetirizine in the Prophylactic Treatment of Seasonal Allergic Rhinitis. Drug Invest 1994;8(4):225-233.