Acts through cyclo-oxygenase-2 (COX-2) inhibition, striking inflammation at its source

Learn how diclofenac reduces inflammation by inhibiting prostaglandin biosynthesis through action on the COX enzymes with selectivity for COX-2, and inhibiting phospholipase A2 activity to reduce the production of inflammatory leukotrienes.1,2,4

Relative potency of diclofenac, ketoprofen and ibuprofen

Diclofenac is a potent anti-inflammatory agent1

Its effect on the COX-2 enzyme means that, unlike non-NSAID medications such as paracetamol, diclofenac not only provides pain relief but also treats inflammation – a root cause of pain.2,4

Diclofenac, an NSAID (and therefore in the same drug class as ketoprofen and ibuprofen), shows marked potency in its inhibition of the COX-2 enzyme.5

Diclofenac targets inflammation to strike pain at its source

Diclofenac-containing products

Voltaren Triple Effect 1.16% Emulgel

Voltaren Emulgel 1%

100g Voltaren Emulgel contains 1.16g diclofenac diethylamine as active ingredient, corresponsing to 1g diclofenac sodium.6

For the symptomatic treatment of osteoarthritis of small and medium joints located close to the skin such as the finger joints or knee joints.6

Diclofenac – a potent anti-inflammatory ingredient1

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Diclofenac-containing products

Learn more about Voltaren products that contain this potent anti-inflammatory ingredient.1


Topical vs systemic non-steroidal anti-inflammatory drugs (NSAIDs)

Topical vs systemic non-steroidal anti-inflammatory drugs (NSAIDs): a guide to clinical practice

Watch Dr Martin Johnson, GP, review the mechanism of action of NSAIDs and compare the benefits and potential drawbacks of topical versus systemic formulations.


Educational resources

Educational resources

Access detailed clinical information about diclofenac.