Explore our research into oral health
The resources on this page are here to give you more insight into the deep science that drives GSK’s oral health research.
We’ve included clinical summaries of our scientific research, videos of our technologies in action and personal insights from experts and patients.
Educational resources
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In vitro study of fluoride uptake into dentine after using Sensodyne Repair & Protect toothpaste
This study used dynamic secondary ion mass spectrometry to investigate the uptake of fluoride into human dentine following treatment with either a test toothpaste or Sensodyne Repair & Protect toothpaste for dentine hypersensitivity.
GSK data on file, 142234.
Long-term impact of NovaMin toothpaste on oral health
This study assessed the effect of continuous management of dentine hypersensitivity with twice-daily use of 5% NovaMin toothpaste over 24 weeks on oral health measures, using the Dentine Hypersensitivity Experience Questionnaire (DHEQ).
NovaMin toothpaste for dentine hypersensitivity
This double-blind, placebo-controlled, randomised study compared the clinical efficacy of a toothpaste containing 5% NovaMin with a toothpaste containing 10% strontium chloride on dentine hypersensitivity.
Du Min Q et al. Am J Dent 2008; 21:210–214.
NovaMin technology and dentine tubule occlusion
The authors of this study employed in vitro examination techniques to visually and chemically characterise how NovaMin technology occludes dentinal tubules in order to treat dentine hypersensitivity.
Earl JS et al. J Clin Dent 2011; 22:62–67.
Hardness and acid resistance of dentine surface layer following treatment with Sensodyne Repair & Protect
This study compared the hardness and acid resistance of the hydroxyapatite-like layer formed over the surface of dentine following treatment with either a test toothpaste or Sensodyne Repair & Protect with NovaMin.
GSK data on file, ML584.
Clinical efficacy of NovaMin toothpaste
This triple-blind, placebo-controlled, randomised clinical trial compared the efficacy of two toothpastes, containing either 5% NovaMin or 5% potassium nitrate, on dentine hypersensitivity in subjects with at least two hypersensitive teeth.
Pradeep AR, Sharma A. J Periodontol 2010; 81:1167–1173.
Efficacy of NovaMin, Sensodent-K and Colgate Dental Cream
This double-blind, randomised controlled trial compared the safety and efficacy of a toothpaste containing 5% NovaMin with a toothpaste containing 5% potassium nitrate and Colgate Dental Cream on dentine hypersensitivity.
Salian S et al. J Clin Dent 2012; 21:82–87.
Dentine Hypersensitivity Experience Questionnaire (DHEQ)
This study is a pooled analysis of seven GSK clinical trials that assessed the reliability, validity and longitudinal responsiveness of the DHEQ as a measure of oral health-related quality of life. The authors also conducted exploratory analyses and validation of the short forms of the DHEQ.
GSK data on file, RH02026.
Short-term relief from dentine hypersensitivity
Three randomised controlled clinical trials compared the efficacy and safety of a toothpaste containing 0.454% stannous fluoride with a toothpaste containing 0.76% sodium monofluorophophate to relieve dentine hypersensitivity after single use and 3 days of twice-daily use.
GSK data on file: Study [1] 205697; Study [2] 205710; Study [3] 207211.
Hypersensitivity relief after 8 weeks of using stannous fluoride toothpaste
This randomised clinical study compared the efficacy of a toothpaste containing 0.454% stannous fluoride with a standard fluoride toothpaste for the relief of dentine hypersensitivity after 8 weeks of twice-daily use.
Parkinson CR et al. Am J Dent 2015; 28:190–196.
Dab-on study
This single-centre, randomised controlled study investigated dentine hypersensitivity relief after a single direct application of 0.454% stannous fluoride toothpaste and after 3 days of twice-daily use, compared with a control toothpaste containing 0.76% sodium monofluorophosphate.
Seong J et al. J Dent Res 2017; 96:0215.
Hydraulic conductance assessment of dentine permeability with Sensodyne toothpastes
This study used the hydraulic conductance in vitro model to compare changes in dentine permeability after treatment with Sensodyne Rapid Relief or an existing Sensodyne stannous fluoride formulation.
Khan SY, Wilson R. J Dent Res 2017; 96:2122.
Videos
Patient-reported outcomes
Watch Barry Gibson, Professor of Medical Sociology at the School of Clinical Dentistry, University of Sheffield, UK, discuss the importance of patient-reported outcomes.
Why develop the DHEQ?
Watch Peter Robinson, Head of Bristol Dental School and Professor of Dental Public Health at the University of Bristol, UK, discuss why the Dentine Hypersensitivity Experience Questionnaire (DHEQ) was developed.
NovaMin helps protect against hypersensitivity
On making contact with saliva, NovaMin initiates a cascade of ionic exchanges, resulting in a rise in local pH level. This allows NovaMin particles to bind to collagen fibres in exposed dentine. Once bound, NovaMin particles act as calcium and phosphate reservoirs, forming a robust hydroxyapatite-like layer over exposed dentine tubules to help protect against dentine hypersensitivity pain.
Stannous fluoride formulation accelerates occlusion of exposed dentine tubules
Sensodyne stannous fluoride formulations have a balance of active stannous fluoride and bio-adhesive polymer which accelerates occlusion of dentine tubules, providing relief from dentine hypersensitivity.
