Advil® DUAL ACTION

Advil® DUAL ACTION MOA

A fixed-dose, pain-fighting pair

Advil® DUAL ACTION is a combination of ibuprofen and acetaminophen—two distinct mechanisms of action (MOA) working together to fight pain.

But how do they work together?

Ibuprofen molecule

Ibuprofen

Ibuprofen, a “traditional” NSAID*, decreases the synthesis of pain- and inflammation-promoting prostaglandins via nonselective inhibition of COX-1 and COX-2.1

*Nonsteroidal anti-inflammatory drug.

Acetaminophen molecule

Acetaminophen

Acetaminophen, a non-NSAID analgesic, is believed to exert its effects via CNS COX inhibition and activation of central serotonergic pathways.1,2

Advil® DUAL ACTION dual MOA

The best of both worlds

Working together, the active ingredients in Advil® DUAL ACTION fight pain using two different approaches to maximize efficacy while requiring lower doses of each medicine.3

For more information on how well this works, please review our efficacy below.

Advil® DUAL ACTION efficacy

Advil® DUAL ACTION is greater than the sum of its parts

In a clinical study, Advil® DUAL ACTION provided significantly greater analgesic efficacy across primary and secondary endpoints than either ibuprofen 250 mg or acetaminophen 650 mg alone.3

Advil® DUAL ACTION efficacy icons

Fast, long, and strong

Advil® DUAL ACTION has a fast onset of action, has a longer duration of relief than ibuprofen 250 mg and acetaminophen 650 mg, and is superior to both ibuprofen 250 mg or acetaminophen 650 mg alone.3

Advil® DUAL ACTION safety

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Names you know and trust

Advil® DUAL ACTION combines two of the most widely used analgesics in the world, both with established efficacy and safety profiles.1,2,4

Advil® DUAL ACTION has a favorable safety profile and is consistent with the known profiles of each active ingredient.3

In efficacy and safety trials, no serious adverse events (AE) or deaths were recorded, with all AEs categorized as mild or moderate.3

In fact, the most commonly reported AEs occurred most frequently in the placebo group. No new safety concerns were identified with Advil® DUAL ACTION compared to each ingredient alone.

Recommend Advil® DUAL ACTION for pain relief with lower doses of each medication

Advil® DUAL ACTION dosing

  • Advil® DUAL ACTION has a favorable dosing schedule that requires lower doses of each medicine over time for adults and children 12 years of age and older:

    • 2 tablets every 8 hours
    • Maximum of 6 tablets over 24 hours
  • Less ibuprofen

    With Advil® DUAL ACTION, the maximum daily allowance of ibuprofen is 750 mg vs 1200 mg maximum daily allowance for ibuprofen alone. When you take Advil® DUAL ACTION, you’re taking 37.5% less ibuprofen.

  • Less acetaminophen

    With Advil® DUAL ACTION, the maximum daily allowance of acetaminophen is 1500 mg vs 4000 mg maximum daily allowance for acetaminophen alone. When you take Advil® DUAL ACTION, you’re taking 62.5% less acetaminophen.

Learn more about Advil® DUAL ACTION

Drug Facts and Dosing

Advil® DUAL ACTION Drug Facts and Dosing

The drug facts contain all you need to know about the drug, as well as NSAID and acetaminophen warnings.

Learn more

Frequently asked questions

Frequently Asked Questions

This resource helps answer common questions about Advil® DUAL ACTION.

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