Advil® DUAL ACTION
A fixed-dose, pain-fighting pair
Advil® DUAL ACTION is a combination of ibuprofen and acetaminophen—two distinct mechanisms of action (MOA) working together to fight pain.
But how do they work together?
Ibuprofen
Ibuprofen, a “traditional” NSAID*, decreases the synthesis of pain- and inflammation-promoting prostaglandins via nonselective inhibition of COX-1 and COX-2.1
*Nonsteroidal anti-inflammatory drug.
Acetaminophen
Acetaminophen, a non-NSAID analgesic, is believed to exert its effects via CNS COX inhibition and activation of central serotonergic pathways.1,2
The best of both worlds
Working together, the active ingredients in Advil® DUAL ACTION fight pain using two different approaches to maximize efficacy while requiring lower maximum daily doses of each medicine.3
For more information on how well this works, please review our efficacy below.
Fast, long, and strong
Advil® DUAL ACTION has a fast onset of action, provides 8 hours of tough pain relief, and is superior to both ibuprofen 250 mg or acetaminophen 650 mg alone.3
Names you know and trust
Advil® DUAL ACTION combines two of the most widely used analgesics in the world, both with established efficacy and safety profiles.1,2,4
Advil® DUAL ACTION has a favorable safety profile and is consistent with the known profiles of each active ingredient.3
In efficacy and safety trials, no serious adverse events (AE) or deaths were recorded, with all AEs categorized as mild or moderate.3
In fact, the most commonly reported AEs occurred most frequently in the placebo group. No new safety concerns were identified with Advil® DUAL ACTION compared to each ingredient alone.
Recommend Advil® DUAL ACTION for pain relief with lower maximum daily doses of each medication
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Less ibuprofen
With Advil® DUAL ACTION, the maximum daily allowance of ibuprofen is 750 mg vs 1200 mg, which is the maximum daily allowance for ibuprofen alone. When you take Advil® DUAL ACTION, you’re taking 37.5% less ibuprofen.
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Less acetaminophen
With Advil® DUAL ACTION, the maximum daily allowance of acetaminophen is 1500 mg vs 4000 mg, which is the maximum daily allowance for acetaminophen alone. When you take Advil® DUAL ACTION, you’re taking 62.5% less acetaminophen.
Learn more about Advil® DUAL ACTION
Advil® DUAL ACTION Drug Facts and Dosing
The drug facts contain all you need to know about the drug, as well as NSAID and acetaminophen warnings.
Frequently Asked Questions
This resource helps answer common questions about Advil® DUAL ACTION.
