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Advil^® DUAL ACTION

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Efficacy
Safety
Dosing

A fixed-dose, pain-fighting pair

Advil^® DUAL ACTION is a combination of ibuprofen and acetaminophen—two distinct mechanisms of action (MOA) working together to fight pain.

But how do they work together?

Ibuprofen

Ibuprofen, a “traditional” NSAID*, decreases the synthesis of pain- and inflammation-promoting prostaglandins via nonselective inhibition of COX-1 and COX-2.¹

*Nonsteroidal anti-inflammatory drug.

Acetaminophen

Acetaminophen, a non-NSAID analgesic, is believed to exert its effects via CNS COX inhibition and activation of central serotonergic pathways.^1,2

The best of both worlds

Working together, the active ingredients in Advil^® DUAL ACTION fight pain using two different approaches to maximize efficacy while requiring lower doses of each medicine.³

For more information on how well this works, please review our efficacy below.

Advil^® DUAL ACTION is greater than the sum of its parts

In a clinical study, Advil^® DUAL ACTION provided significantly greater analgesic efficacy across primary and secondary endpoints than either ibuprofen 250 mg or acetaminophen 650 mg alone.³

Fast, long, and strong

Advil^® DUAL ACTION has a fast onset of action, has a longer duration of relief than ibuprofen 250 mg and acetaminophen 650 mg, and is superior to both ibuprofen 250 mg or acetaminophen 650 mg alone.³

Advil^®DUAL ACTION safety

Names you know and trust

Advil^® DUAL ACTION combines two of the most widely used analgesics in the world, both with established efficacy and safety profiles.^1,2,4

Advil^® DUAL ACTION has a favorable safety profile and is consistent with the known profiles of each active ingredient.³

In efficacy and safety trials, no serious adverse events (AE) or deaths were recorded, with all AEs categorized as mild or moderate.³

In fact, the most commonly reported AEs occurred most frequently in the placebo group. No new safety concerns were identified with Advil^® DUAL ACTION compared to each ingredient alone.

Recommend Advil^® DUAL ACTION for pain relief with lower doses of each medication

Advil^® Dual Action

An effective combination of ibuprofen and acetaminophen that fights pain in 2 ways.

Advil^® DUAL ACTION dosing

Dosing
Advil^® DUAL ACTION has a favorable dosing schedule that requires lower doses of each medicine over time for adults and children 12 years of age and older:

2 tablets every 8 hours

Maximum of 6 tablets over 24 hours
Less ibuprofen

With Advil^® DUAL ACTION, the maximum daily allowance of ibuprofen is 750 mg vs 1200 mg maximum daily allowance for ibuprofen alone. When you take Advil^®DUAL ACTION, you’re taking 37.5% less ibuprofen.
Less acetaminophen

With Advil^® DUAL ACTION, the maximum daily allowance of acetaminophen is 1500 mg vs 4000 mg maximum daily allowance for acetaminophen alone. When you take Advil^® DUAL ACTION, you’re taking 62.5% less acetaminophen.