Children's FLONASE Product Overview

*Mechanism vs most allergy pills. Children’s FLONASE acts on multiple inflammatory mediators (histamine, prostaglandins, cytokines, tryptases, chemokines, and leukotrienes). The exact number and precise mechanism are unknown.

References

1. Derendorf, H. and Meltzer, E. O. Molecular and Clinical Pharmacology of Intranasal Corticosteroids: Clinical and Therapeutic Implications. Allergy: European Journal of Allergy and Clinical Immunology. 63(10): 1292-1300, 2008.
2. Gelfand, E. W. Inflammatory Mediators in Allergic Rhinitis. Journal of Allergy and Clinical Immunology. 114(5 SUPPL.): S135-S138, 2004.
3. White, M. V. and Kaliner, M. A. Mediators of Allergic Rhinitis. Journal of Allergy and Clinical Immunology. 90(4 II): 699-704, 1992.
4. Bachert, C. and Geveart, P. Effect of Intranasal Corticosteroids on Release of Cytokines and Inflammatory Mediators. Allergy: European Journal of Allergy and Clinical Immunology, Supplement. 54(57): 116-123, 1999.
5. Haye, R. and Gomez, E. G. A Multicentre Study to Assess Long-Term Use of Fluticasone Propionate Aqueous Nasal Spray in Comparison With Beclomethasone Dipropionate Aqueous Nasal Spray in the Treatment of Perennial Rhinitis. Rhinology. 31(4): 169-174, 1993.
6. Bernstein, D. I., Levy, A. L., Hampel, F. C., Baidoo, C. A. et al. Treatment With Intranasal Fluticasone Propionate Significantly Improves Ocular Symptoms in Patients With Seasonal Allergic Rhinitis. Clinical and Experimental Allergy. 34(6): 952-957, 2004.
7. DeWester, J., Philpot, E. E., Westlund, R. E., Cook, C. K. et al. The Efficacy of Intranasal Fluticasone Propionate in the Relief of Ocular Symptoms Associated With Seasonal Allergic Rhinitis. Allergy and Asthma Proceedings. 24(5): 331-337, 2003.
8. Data on file, GlaxoSmithKline. (GSK: Result Summary for Study FNM30034. Http://Www.Gsk-Clinicalstudyregister.Com/. 5-12-2005).
9. FLONASE Drug Facts Label.