Stannous fluoride formulation

Stannous fluoride formulation accelerates occlusion of exposed dentine tubules

The unique formulation – with a balance of active stannous fluoride and bio-adhesive polymer – accelerates occlusion of dentine tubules by:1

  • Providing improved bio-adhesion*3
  • Forming a gel-like scaffold to hold the stannous in place1

*vs. toothpaste containing 0.454% stannous fluoride and lower polymer level

Study summary

Representative FIB-SEM image of dentine tubules

The Sensodyne Rapid Relief stannous fluoride formulation occludes exposed dentine tubules, helping prevent the movement of fluid1,3–5

Representative FIB-SEM image of dentine tubules treated with Sensodyne Rapid Relief, combining multiple imaging techniques (STEM-EDS, DSIMS, FIB-SEM/EDS). The stannous fluoride formulation is shown to extend up into the dentine tubules.4,5

DSIMS, dynamic secondary ion mass spectrometry; FIB-SEM/EDS, focused ion beam scanning electron microscope/energy-dispersive spectroscopy; STEM-EDS, scanning transmission electron microscope energy-dispersive spectroscopy

Clinical summary

Clinically proven fast relief 6–8

  • Stannous fluoride is delivered in an anhydrous (non-aqueous) formulation that is primed to react in the mouth

    Anhydrous formulation primed to react in the mouth
    • The non-aqueous formulation ensures stannous fluoride becomes active when in contact with saliva
    • The facilitating polymer becomes adhesive in saliva, sticking to dentine and helping to trap stannous ions
  • Engineered for speed – a unique formulation that accelerates occlusion of exposed dentine tubules 1

    Fluid flow occlusion

    Sensodyne Rapid Relief has a unique formulation of stannous fluoride with facilitating bio-adhesive polymer, and has been shown to reduce fluid flow through dentine tubules by 127% compared with a regular stannous fluoride toothpaste after one application in vitro.*1

    Chart adapted from Khan et al. 20171SnF2, stannous fluoride *vs. toothpaste containing 0.454% stannous fluoride and lower polymer level. Although the active ingredients are the same, the way the toothpastes are formulated affects the way they work.1 A four-day hydraulic conductance study measuring the fluid flow rates through dentine tubules of two toothpaste formulations. Fluid flow rates were measured after the initial treatment and on Days 1–4. The Pashley hydraulic conductance model and Earles’ solution passed through dentine tubules when a simulation of pulpal pressure was used

    Study summary

  • Dentine tubule occlusion that can withstand exposure to dietary acids9

    SEM images of dentine

    In vitro SEM images of the dentine surface after 2 minutes’ exposure to Sensodyne Rapid Relief toothpaste slurries twice daily.9

    SEM, scanning electron microscope

    Study summary

  • Reduction in dentine hypersensitivity after brushing sensitive areas6

    Relief after first brush

    Sensodyne Rapid Relief with stannous fluoride and bio-adhesive polymer is clinically proven to relieve sensitivity from the first brush.6

    Chart adapted from GSK data on file 2072116Two additional studies have been conducted: GSK data on file 205710 showing 7% reduction in Schiff score from baseline after first brush, and GSK data on file 205697 showing 18% reduction in Schiff score from baseline after first brush6

    Clinical summary

  • Reduction in dentine hypersensitivity after a single ‘dab-on’ application8

    Relief after ‘dab-on’

    Sensodyne Rapid Relief with stannous fluoride and bio-adhesive polymer is clinically proven to relieve sensitivity in just 60 seconds.8

    Chart adapted from Seong et al. 20178'Dab-on' refers to direct application with finger to sensitive teeth Two additional studies have been conducted: GSK data on file 205072 showing 14% reduction in Schiff score from baseline after a single application, and GSK data on file 207212 showing 29% reduction in Schiff score from baseline after a single application

    Clinical summary

  • Sustained relief in dentine hypersensitivity with long-term use10

    Hypersensitivity relief after long-term use

    A 63% reduction in dentine hypersensitivity has been shown after 8 weeks of brushing with Sensodyne Rapid Relief.10

    Chart adapted from Parkinson et al. 201510

    Clinical summary

  • Effective plaque control to help improve gum health11

    In vitro plaque model

    Early and mature plaque are affected by antimicrobial action of stannous fluoride found in Sensodyne Sensitivity & Gum11

    Significant loss of viability of in vitro plaque when treated with Sensodyne Sensitivity & Gum. Confocal Laser Scanning Microscopy (CLSM) images of in vitro plaque models with 3 (left), 7 (centre) or 10 (right) dental plaque bacterial species. The protocol and bacteria species used followed a model previously described in Malcolm et al. (2016) and Stephen et al. (2016).12,13 Samples treated with slurry of 16% w/v toothpaste for 3 minutes. Control represents untreated in vitro plaque models of 3, 7 or 10 bacterial species, respectively.

  • Occlusion of exposed dentine tubules11

    Sensodyne Sensitivity & Gum, with stannous fluoride, occludes exposed dentine tubules to help relieve sensitivity14–17

Rapid relief

Sensodyne Rapid Relief toothpaste

Sensodyne Rapid Relief toothpaste is powered by stannous fluoride in a unique formulation that accelerates occlusion of exposed dentine tubules.1,3

Sensodyne Sensitivity & Gum packshot

Sensodyne Sensitivity & Gum toothpaste

Sensodyne Sensitivity & Gum is a specialist dual relief toothpaste with stannous fluoride, clinically proven to relieve dentine hypersensitivity and improve gum health.18,19

Sensodyne - the Number 1 dentist recommended brand for sensitive teeth*

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