NOVAMIN formulations build a hydroxyapatite-like layer over and within dentin tubules
NOVAMIN (Calcium Sodium Phosphosilicate) is specially formulated in Sensodyne Repair & Protect helps to repair exposed dentin:*1,2
- Once in contact with saliva, NOVAMIN initiates a cascade of ionic exchanges
- This results in a rise in pH level in the localised environment, which allows NOVAMIN to bind to collagen fibres in exposed dentin
- Once bound to dentin, NOVAMIN particles act as calcium and phosphate reservoirs, forming a robust and reparative hydroxyapatite-like layer over exposed dentin tubules to help protect against dentin hypersensitivity pain
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protectionRead more
NOVAMIN forms a robust hydroxyapatite-like layer over exposed dentin and within exposed dentin tubules*2-5
An in vitro cross-section, SEM image of hydroxyapatite-like layer formed by supersaturated NOVAMIN solution in artificial saliva after five days (no brushing).1
SEM, scanning electron microscopeSEM image adapted from Earl et al. 20114*It forms a protective layer over the sensitive area of the teeth. Brush twice a day for lasting sensitivity protection.
NOVAMIN helps form a protective layer over exposed dentin2-5
TEM image of dentin at 2000nm
The occluded dentin tubule runs from top to bottom of the image.1
TEM image of dentin at 500nm
High magnification showing NovaMin as the occluding material adjacent to inner wall of dentin tubule.1
TEM image of dentin at 200nm
Very high magnification of the previous image showing crystalline calcium phosphate deposited adjacent to and among collagen fibres of dentin.1
TEM, transmission electron microscope.
TEM images are of dentin after 5 days of in vitro NOVAMIN treatment and are adapted from Earl et al. 20111.
Scanning electron microscope images of the dentin surface before brushing with NOVAMIN-formulated toothpaste and the resistant layer formed after1
NOVAMIN is a Bioglass that uses the natural building blocks of teeth3 to remineralise exposed dentin, forming a crystalline hydroxyapatite-like layer. 1,3,6-11
- Calcium and phosphorous are the two main components of hydroxyapatite, the mineral which teeth are made of – this is key to the mode of action of NOVAMIN
The Calcium to phosphorus ratio of the hydroxyapatite-like layer is ~1.67, similar to that of dentin and hydroxyapatite1
When overlaid, energy-dispersive X-ray (EDX) microscopy plots of the new reparative layer* (hydroxyapatite-like layer) and the dentin surface confirm their similar inorganic compositions.
*Forms a protective layer over the sensitive areas of the teeth. Brush twice a day for lasting sensitivity protection.
In this study there was a 53% reduction in the proportion of teeth qualifying as sensitive in response to an evaporative air test (Schiff Sensitivity Scale) after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NOVAMIN.*13,14
Chart adapted from GSK Data on File RH0189713*Qualifying sensitive teeth met the following inclusion criteria: signs of EAR, GI ≤1, clinical mobility=0, no dentition exclusion and sensitivity to a qualifying air blast. ITT population (n=75)
In this study there was a 2.2x improvement in dentin hypersensitivity in response to tactile pressure after 24 weeks of twice-daily brushing with Sensodyne Repair & Protect with 5% NOVAMIN.*13,14
Chart adapted from GSK Data on File RH0189713**Maximum tactile pressure was 80g. An increase in tactile threshold indicates an improvement in dentin hypersensitivity. ITT population (n=75)