Sensodyne Science: Stannous Fluoride Formulation

Stannous fluoride formulation accelerates occlusion of exposed dentin tubules

Study summary

Representative FIB-SEM image of dentin tubules

The Sensodyne Rapid Relief stannous fluoride formulation occludes exposed dentin tubules, helping prevent the movement of fluid1,3-5

Representative FIB-SEM image of dentin tubules treated with Sensodyne Rapid Relief, combining multiple imaging techniques (STEM-EDS, DSIMS, FIB-SEM/EDS). The stannous fluoride formulation is shown to extend into the dentin tubules.4,5

DSIMS, dynamic secondary ion mass spectrometry; FIB-SEM/EDS, focused ion beam scanning electron microscope/energy-dispersive spectroscopy; STEM-EDS, scanning transmission electron microscope energy-dispersive spectroscopy

Clinical summary

Clinically proven sensitivity relief in 60 seconds8*

*When used as directed.

  • Stannous fluoride is delivered in an anhydrous (non-aqueous) formulation that is primed to react in the mouth

    Anhydrous formulation that reacts in the mouth
    • The non-aqueous formulation ensures stannous fluoride becomes active when in contact with saliva
    • The stannous fluoride formulation becomes activated in saliva, sticking to dentin and tooth structure
  • A stannous fluoride formulation that has been engineered for speed

    Fluid flow occlusion after one application

    In this study, Sensodyne Rapid Relief stannous fluoride formulation with inactive polymer, has been shown to reduce fluid flow through dentin tubules as compared to a regular stannous fluoride toothpaste after one application in vitro.*1

    Chart adapted from Khan et al. 20171

    SnF2, stannous fluoride

    *vs. another toothpaste containing 0.454% stannous fluoride. Although the active ingredients are the same, the way the toothpastes are formulated affects the way they work.1 A four-day hydraulic conductance study measuring the fluid flow rates through dentin tubules of two toothpaste formulations. Fluid flow rates were measured after the initial treatment and on Days 1–4. The Pashley hydraulic conductance model and Earles’ solution passed through dentin tubules when a simulation of pulpal pressure was used

    Study summary

  • Dentin tubule occlusion that withstands exposure to dietary acids 9

    SEM images of dentin

    SEM* imagery of the dentin surface pre-treatment and post-treatment followed by an acid challenge in vitro.6

    *SEM, scanning electron microscope

    Study summary

  • Reduction in dentine hypersensitivity after brushing sensitive areas 8

    Relief after first brush

    Sensodyne Rapid Relief with stannous fluoride is clinically proven to relieve sensitivity from the first brush.6

    Chart adapted from GSK data on file 2072116

    Two additional studies have been conducted: GSK data on file 205710 showing 7% reduction in Schiff score from baseline after first brush, and GSK data on file 205697 showing 18% reduction in Schiff score from baseline after first brush9

  • Reduction in dentine hypersensitivity after a single ‘dab-on’ application 8

    Relief after ‘dab-on’

    Sensodyne Rapid Relief with stannous fluoride is clinically proven to relieve sensitivity in just 60 seconds.8

    Chart adapted from Seong et al. 20178

    'Dab-on' refers to direct application with finger to sensitive teeth.

    Two additional studies have been conducted: GSK data on file 205072 showing 14% reduction in Schiff score from baseline after a single application, and GSK data on file 207212 showing 29% reduction in Schiff score from baseline after a single application.

  • Sensitivity relief that continues to improve with twice-daily use 7

    Continued hypersensitivity relief after long-term use

    A continued reduction in dentin hypersensitivity has been shown after 8 weeks of brushing with Sensodyne Rapid Relief.10 It provides long-lasting protection from sensitivity with twice daily brushing.

    Chart adapted from Parkinson et al. 201510

    *0.76% w/w sodium monofluorophosphate toothpaste

    Clinical summary

Rapid relief

Sensodyne Rapid Relief toothpaste

Sensodyne Rapid Relief toothpaste is engineered for speed.1,2 It is powered by stannous fluoride in a formulation that accelerates occlusion of exposed dentine tubules, providing sensitivity relief in just 60 seconds.10*

*When used as directed.

Sensodyne – #1 Dentist recommended brand for sensitive teeth11

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